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GO:0003918: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (Molecular function)

"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2." [PMID:8811192]


There are 2977 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_333 Actinostachys digitata 2.2 % 2.6e-05 0.002644
Cluster_50 Alsophila latebrosa 0.51 % 0.015082 0.049253
Cluster_50 Amblovenatum opulentum 0.7 % 0.007922 0.019602
Cluster_38 Amborella trichopoda 1.47 % 0.014847 0.033299
Cluster_59 Cyanophora paradoxa 1.96 % 0.000251 0.003654
Cluster_19 Cyanophora paradoxa 1.04 % 0.000892 0.004332
Cluster_149 Ceratopteris richardii 1.61 % 0.008383 0.031227
Cluster_53 Ceratopteris richardii 1.33 % 0.000163 0.001072
Cluster_18 Diplazium proliferum (Lam.) Kaulf. 0.56 % 0.01138 0.041927
Cluster_151 Davallia denticulata 1.96 % 0.003872 0.024758
Cluster_51 Ginkgo biloba 2.67 % 4.9e-05 0.00034
Cluster_11 Ginkgo biloba 0.83 % 0.017448 0.039803
Cluster_13 Lindsaea ensifolia 3.45 % 2.6e-05 0.002943
Cluster_109 Microlepia speluncae 0.97 % 0.00839 0.02338
Cluster_78 Ophioglossum reticulatum 1.69 % 0.003874 0.009212
Cluster_27 Oryza sativa 0.64 % 0.014709 0.040545
Cluster_79 Picea abies 1.47 % 4.1e-05 0.000136
Cluster_26 Pyrrosia piloselloides 0.75 % 0.006177 0.024959
Cluster_146 Stenochlaena palustris 1.68 % 8.9e-05 0.000525
Cluster_37 Tectaria incisa 0.6 % 0.010722 0.02675
Cluster_15 Tectaria incisa 0.54 % 0.011809 0.035426
Cluster_15 Zea mays 2.94 % 0.0 1e-06
Cluster_11 Arabidopsis thaliana 1.69 % 0.019041 0.0444
Sequences (2977) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms