AT1G63490

Description : transcription factor jumonji (jmjC) domain-containing protein

Gene families : OG0001130 (OrthoFinder output from all 47 species) Phylogenetic Tree(s): OG0001130_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AT1G63490

Target	Alias	Description	ECC score	Gene Family Method
AMTR_s00009p00253500	evm_27.TU.AmTr_v1...	RNA biosynthesis.transcriptional activation.JUMONJI...	0.08	OrthoFinder output from all 47 species
Adi_g012015	No alias	not classified & original description: none	0.03	OrthoFinder output from all 47 species
Adi_g042525	No alias	not classified & original description: none	0.02	OrthoFinder output from all 47 species
Adi_g055868	No alias	histone demethylase *(KDM5) & original description: none	0.07	OrthoFinder output from all 47 species
Adi_g107372	No alias	not classified & original description: none	0.03	OrthoFinder output from all 47 species
Aev_g15008	No alias	histone demethylase *(KDM5) & original description: none	0.03	OrthoFinder output from all 47 species
Ala_g08112	No alias	histone demethylase *(KDM5) & original description: none	0.09	OrthoFinder output from all 47 species
Als_g62631	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.03	OrthoFinder output from all 47 species
Aob_g13634	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.05	OrthoFinder output from all 47 species
Aob_g17236	No alias	histone demethylase *(KDM5) & original description: none	0.03	OrthoFinder output from all 47 species
Aspi01Gene28386.t1	Aspi01Gene28386	histone demethylase *(KDM5) & original description: none	0.05	OrthoFinder output from all 47 species
Aspi01Gene34964.t2	PKDM7D, Aspi01Gene34964	histone demethylase *(PKDM7) & original description: none	0.03	OrthoFinder output from all 47 species
Aspi01Gene68630.t1	PKDM7D, Aspi01Gene68630	histone demethylase *(PKDM7) & original description: none	0.04	OrthoFinder output from all 47 species
Azfi_s0001.g000131	PKDM7D	histone demethylase *(PKDM7) & original description: CDS=166-5457	0.03	OrthoFinder output from all 47 species
Azfi_s0103.g044628	PKDM7D	histone demethylase *(PKDM7) & original description: CDS=238-3396	0.04	OrthoFinder output from all 47 species
Cba_g01359	No alias	histone demethylase *(KDM5) & original description: none	0.03	OrthoFinder output from all 47 species
Ceric.01G024900.1	Ceric.01G024900	histone demethylase *(KDM5) & original description:...	0.12	OrthoFinder output from all 47 species
Ceric.09G000100.1	PKDM7D, Ceric.09G000100	histone demethylase *(PKDM7) & original description:...	0.06	OrthoFinder output from all 47 species
Ceric.28G058700.1	PKDM7D, Ceric.28G058700	histone demethylase *(PKDM7) & original description:...	0.02	OrthoFinder output from all 47 species
Cre12.g514250	No alias	RNA biosynthesis.transcriptional activation.JUMONJI...	0.01	OrthoFinder output from all 47 species
Dcu_g07179	No alias	histone demethylase *(KDM5) & original description: none	0.09	OrthoFinder output from all 47 species
Dcu_g14428	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.04	OrthoFinder output from all 47 species
Dde_g06623	No alias	histone demethylase *(KDM5) & original description: none	0.02	OrthoFinder output from all 47 species
Ehy_g21285	PKDM7B, JMJ14	histone demethylase *(PKDM7) & original description: none	0.03	OrthoFinder output from all 47 species
GSVIVT01019761001	No alias	RNA biosynthesis.transcriptional activation.JUMONJI...	0.07	OrthoFinder output from all 47 species
GSVIVT01023517001	PKDM7D	RNA biosynthesis.transcriptional activation.JUMONJI...	0.11	OrthoFinder output from all 47 species
GSVIVT01028351001	PKDM7D	RNA biosynthesis.transcriptional activation.JUMONJI...	0.04	OrthoFinder output from all 47 species
Gb_26073	No alias	histone demethylase (KDM5). transcription factor (JUMONJI)	0.06	OrthoFinder output from all 47 species
Gb_27431	PKDM7D	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.03	OrthoFinder output from all 47 species
LOC_Os05g10770.1	PKDM7D, LOC_Os05g10770	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.06	OrthoFinder output from all 47 species
LOC_Os05g23670.1	LOC_Os05g23670	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.02	OrthoFinder output from all 47 species
Len_g14189	No alias	histone demethylase *(KDM5) & original description: none	0.04	OrthoFinder output from all 47 species
Len_g18977	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.04	OrthoFinder output from all 47 species
Lfl_g04296	No alias	histone demethylase *(KDM5) & original description: none	0.1	OrthoFinder output from all 47 species
MA_10434186g0010	PKDM7D	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.04	OrthoFinder output from all 47 species
MA_10436180g0010	No alias	no hits & (original description: none)	0.05	OrthoFinder output from all 47 species
MA_11526g0010	No alias	Putative lysine-specific demethylase JMJ16...	0.05	OrthoFinder output from all 47 species
MA_91656g0010	No alias	no hits & (original description: none)	0.04	OrthoFinder output from all 47 species
Mp6g20340.1	PKDM7D	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.03	OrthoFinder output from all 47 species
Mp8g17910.1	No alias	histone demethylase (KDM5). transcription factor (JUMONJI)	0.06	OrthoFinder output from all 47 species
Msp_g13349	No alias	histone demethylase *(KDM5) & original description: none	0.08	OrthoFinder output from all 47 species
Nbi_g02485	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.03	OrthoFinder output from all 47 species
Nbi_g38705	No alias	histone demethylase *(KDM5) & original description: none	0.04	OrthoFinder output from all 47 species
Pir_g15994	No alias	histone demethylase *(KDM5) & original description: none	0.03	OrthoFinder output from all 47 species
Pir_g29562	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.02	OrthoFinder output from all 47 species
Pnu_g07515	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.02	OrthoFinder output from all 47 species
Ppi_g54999	PKDM7D	histone demethylase *(PKDM7) & original description: none	0.04	OrthoFinder output from all 47 species
Sacu_v1.1_s0050.g013848	No alias	histone demethylase *(KDM5) & original description: CDS=319-5874	0.05	OrthoFinder output from all 47 species
Sam_g11634	No alias	histone demethylase *(KDM5) & original description: none	0.07	OrthoFinder output from all 47 species
Sam_g18668	No alias	histone demethylase *(PKDM7) & original description: none	0.03	OrthoFinder output from all 47 species
Solyc08g081000.3.1	Solyc08g081000	histone demethylase (KDM5). transcription factor (JUMONJI)	0.03	OrthoFinder output from all 47 species
Spa_g17545	No alias	histone demethylase *(KDM5) & original description: none	0.05	OrthoFinder output from all 47 species
Tin_g12700	No alias	histone demethylase *(KDM5) & original description: none	0.06	OrthoFinder output from all 47 species
Zm00001e030938_P001	PKDM7D, Zm00001e030938	histone demethylase (PKDM7). transcription factor (JUMONJI)	0.06	OrthoFinder output from all 47 species

Type	GO Term	Name	Evidence	Source
BP	GO:0000271	polysaccharide biosynthetic process	None	Extended
BP	GO:0000278	mitotic cell cycle	RCA	Interproscan
BP	GO:0003006	developmental process involved in reproduction	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003700	DNA-binding transcription factor activity	ISS	Interproscan
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	ISM	Interproscan
BP	GO:0005975	carbohydrate metabolic process	None	Extended
BP	GO:0005976	polysaccharide metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006355	regulation of DNA-templated transcription	RCA	Interproscan
BP	GO:0006396	RNA processing	RCA	Interproscan
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0007049	cell cycle	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010228	vegetative to reproductive phase transition of meristem	RCA	Interproscan
BP	GO:0010383	cell wall polysaccharide metabolic process	None	Extended
BP	GO:0010410	hemicellulose metabolic process	None	Extended
BP	GO:0010413	glucuronoxylan metabolic process	RCA	Interproscan
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0016051	carbohydrate biosynthetic process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
BP	GO:0016926	protein desumoylation	RCA	Interproscan
BP	GO:0018193	peptidyl-amino acid modification	None	Extended
BP	GO:0018205	peptidyl-lysine modification	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0022414	reproductive process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0032502	developmental process	None	Extended
BP	GO:0033692	cellular polysaccharide biosynthetic process	None	Extended
BP	GO:0034637	cellular carbohydrate biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0036211	protein modification process	None	Extended
BP	GO:0042743	hydrogen peroxide metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0044036	cell wall macromolecule metabolic process	None	Extended
BP	GO:0044038	cell wall macromolecule biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044262	cellular carbohydrate metabolic process	None	Extended
BP	GO:0044264	cellular polysaccharide metabolic process	None	Extended
BP	GO:0045491	xylan metabolic process	None	Extended
BP	GO:0045492	xylan biosynthetic process	RCA	Interproscan
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050665	hydrogen peroxide biosynthetic process	RCA	Interproscan
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0070589	cellular component macromolecule biosynthetic process	None	Extended
BP	GO:0070592	cell wall polysaccharide biosynthetic process	None	Extended
BP	GO:0070646	protein modification by small protein removal	None	Extended
BP	GO:0070647	protein modification by small protein conjugation or removal	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072593	reactive oxygen species metabolic process	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:0140110	transcription regulator activity	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1903409	reactive oxygen species biosynthetic process	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0000003	reproduction	IEP	HCCA
MF	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IEP	HCCA
BP	GO:0000723	telomere maintenance	IEP	HCCA
BP	GO:0000724	double-strand break repair via homologous recombination	IEP	HCCA
BP	GO:0000725	recombinational repair	IEP	HCCA
BP	GO:0000902	cell morphogenesis	IEP	HCCA
BP	GO:0000904	cell morphogenesis involved in differentiation	IEP	HCCA
BP	GO:0000910	cytokinesis	IEP	HCCA
BP	GO:0000911	cytokinesis by cell plate formation	IEP	HCCA
BP	GO:0000956	nuclear-transcribed mRNA catabolic process	IEP	HCCA
BP	GO:0001558	regulation of cell growth	IEP	HCCA
MF	GO:0003678	DNA helicase activity	IEP	HCCA
MF	GO:0003682	chromatin binding	IEP	HCCA
MF	GO:0004386	helicase activity	IEP	HCCA
MF	GO:0004402	histone acetyltransferase activity	IEP	HCCA
CC	GO:0005622	intracellular anatomical structure	IEP	HCCA
CC	GO:0005737	cytoplasm	IEP	HCCA
BP	GO:0006259	DNA metabolic process	IEP	HCCA
BP	GO:0006302	double-strand break repair	IEP	HCCA
BP	GO:0006310	DNA recombination	IEP	HCCA
BP	GO:0006401	RNA catabolic process	IEP	HCCA
BP	GO:0006402	mRNA catabolic process	IEP	HCCA
BP	GO:0006473	protein acetylation	IEP	HCCA
BP	GO:0006996	organelle organization	IEP	HCCA
BP	GO:0007015	actin filament organization	IEP	HCCA
BP	GO:0007059	chromosome segregation	IEP	HCCA
BP	GO:0007062	sister chromatid cohesion	IEP	HCCA
BP	GO:0007129	homologous chromosome pairing at meiosis	IEP	HCCA
BP	GO:0007131	reciprocal meiotic recombination	IEP	HCCA
BP	GO:0007155	cell adhesion	IEP	HCCA
BP	GO:0007346	regulation of mitotic cell cycle	IEP	HCCA
MF	GO:0008080	N-acetyltransferase activity	IEP	HCCA
MF	GO:0008094	ATP-dependent activity, acting on DNA	IEP	HCCA
BP	GO:0009056	catabolic process	IEP	HCCA
BP	GO:0009057	macromolecule catabolic process	IEP	HCCA
BP	GO:0009303	rRNA transcription	IEP	HCCA
BP	GO:0009628	response to abiotic stimulus	IEP	HCCA
BP	GO:0009653	anatomical structure morphogenesis	IEP	HCCA
BP	GO:0009791	post-embryonic development	IEP	HCCA
BP	GO:0009880	embryonic pattern specification	IEP	HCCA
BP	GO:0009887	animal organ morphogenesis	IEP	HCCA
BP	GO:0009888	tissue development	IEP	HCCA
BP	GO:0009891	positive regulation of biosynthetic process	IEP	HCCA
BP	GO:0009892	negative regulation of metabolic process	IEP	HCCA
BP	GO:0009893	positive regulation of metabolic process	IEP	HCCA
BP	GO:0009894	regulation of catabolic process	IEP	HCCA
BP	GO:0009895	negative regulation of catabolic process	IEP	HCCA
BP	GO:0009908	flower development	IEP	HCCA
BP	GO:0010048	vernalization response	IEP	HCCA
BP	GO:0010072	primary shoot apical meristem specification	IEP	HCCA
BP	GO:0010090	trichome morphogenesis	IEP	HCCA
BP	GO:0010212	response to ionizing radiation	IEP	HCCA
BP	GO:0010332	response to gamma radiation	IEP	HCCA
BP	GO:0010431	seed maturation	IEP	HCCA
BP	GO:0010506	regulation of autophagy	IEP	HCCA
BP	GO:0010507	negative regulation of autophagy	IEP	HCCA
BP	GO:0010557	positive regulation of macromolecule biosynthetic process	IEP	HCCA
BP	GO:0010604	positive regulation of macromolecule metabolic process	IEP	HCCA
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	HCCA
BP	GO:0010629	negative regulation of gene expression	IEP	HCCA
BP	GO:0010638	positive regulation of organelle organization	IEP	HCCA
BP	GO:0016071	mRNA metabolic process	IEP	HCCA
MF	GO:0016303	1-phosphatidylinositol-3-kinase activity	IEP	HCCA
MF	GO:0016307	phosphatidylinositol phosphate kinase activity	IEP	HCCA
MF	GO:0016407	acetyltransferase activity	IEP	HCCA
MF	GO:0016410	N-acyltransferase activity	IEP	HCCA
MF	GO:0016740	transferase activity	IEP	HCCA
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEP	HCCA
BP	GO:0019439	aromatic compound catabolic process	IEP	HCCA
BP	GO:0022402	cell cycle process	IEP	HCCA
BP	GO:0030307	positive regulation of cell growth	IEP	HCCA
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	HCCA
BP	GO:0031325	positive regulation of cellular metabolic process	IEP	HCCA
BP	GO:0031328	positive regulation of cellular biosynthetic process	IEP	HCCA
BP	GO:0031329	regulation of cellular catabolic process	IEP	HCCA
BP	GO:0031330	negative regulation of cellular catabolic process	IEP	HCCA
BP	GO:0032200	telomere organization	IEP	HCCA
BP	GO:0032204	regulation of telomere maintenance	IEP	HCCA
BP	GO:0032501	multicellular organismal process	IEP	HCCA
BP	GO:0032504	multicellular organism reproduction	IEP	HCCA
CC	GO:0032588	trans-Golgi network membrane	IEP	HCCA
BP	GO:0033043	regulation of organelle organization	IEP	HCCA
BP	GO:0033044	regulation of chromosome organization	IEP	HCCA
MF	GO:0034212	peptide N-acetyltransferase activity	IEP	HCCA
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	HCCA
MF	GO:0035004	phosphatidylinositol 3-kinase activity	IEP	HCCA
BP	GO:0035825	homologous recombination	IEP	HCCA
BP	GO:0040019	positive regulation of embryonic development	IEP	HCCA
BP	GO:0042138	meiotic DNA double-strand break formation	IEP	HCCA
BP	GO:0043247	telomere maintenance in response to DNA damage	IEP	HCCA
BP	GO:0043473	pigmentation	IEP	HCCA
BP	GO:0043476	pigment accumulation	IEP	HCCA
BP	GO:0043478	pigment accumulation in response to UV light	IEP	HCCA
BP	GO:0043479	pigment accumulation in tissues in response to UV light	IEP	HCCA
BP	GO:0043480	pigment accumulation in tissues	IEP	HCCA
BP	GO:0043481	anthocyanin accumulation in tissues in response to UV light	IEP	HCCA
MF	GO:0043621	protein self-association	IEP	HCCA
BP	GO:0043687	post-translational protein modification	IEP	HCCA
BP	GO:0044248	cellular catabolic process	IEP	HCCA
BP	GO:0044265	cellular macromolecule catabolic process	IEP	HCCA
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	HCCA
BP	GO:0045010	actin nucleation	IEP	HCCA
BP	GO:0045132	meiotic chromosome segregation	IEP	HCCA
BP	GO:0045595	regulation of cell differentiation	IEP	HCCA
BP	GO:0045893	positive regulation of DNA-templated transcription	IEP	HCCA
BP	GO:0045927	positive regulation of growth	IEP	HCCA
BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	IEP	HCCA
BP	GO:0045995	regulation of embryonic development	IEP	HCCA
BP	GO:0046700	heterocycle catabolic process	IEP	HCCA
BP	GO:0048316	seed development	IEP	HCCA
BP	GO:0048440	carpel development	IEP	HCCA
BP	GO:0048519	negative regulation of biological process	IEP	HCCA
BP	GO:0048522	positive regulation of cellular process	IEP	HCCA
BP	GO:0048523	negative regulation of cellular process	IEP	HCCA
BP	GO:0048608	reproductive structure development	IEP	HCCA
BP	GO:0048856	anatomical structure development	IEP	HCCA
BP	GO:0051094	positive regulation of developmental process	IEP	HCCA
BP	GO:0051128	regulation of cellular component organization	IEP	HCCA
BP	GO:0051130	positive regulation of cellular component organization	IEP	HCCA
BP	GO:0051173	positive regulation of nitrogen compound metabolic process	IEP	HCCA
BP	GO:0051240	positive regulation of multicellular organismal process	IEP	HCCA
BP	GO:0051254	positive regulation of RNA metabolic process	IEP	HCCA
BP	GO:0051276	chromosome organization	IEP	HCCA
BP	GO:0051301	cell division	IEP	HCCA
MF	GO:0052742	phosphatidylinositol kinase activity	IEP	HCCA
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	IEP	HCCA
BP	GO:0061982	meiosis I cell cycle process	IEP	HCCA
BP	GO:0070192	chromosome organization involved in meiotic cell cycle	IEP	HCCA
BP	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEP	HCCA
BP	GO:0090421	embryonic meristem initiation	IEP	HCCA
BP	GO:0090567	reproductive shoot system development	IEP	HCCA
BP	GO:0097435	supramolecular fiber organization	IEP	HCCA
BP	GO:0098781	ncRNA transcription	IEP	HCCA
BP	GO:0098813	nuclear chromosome segregation	IEP	HCCA
MF	GO:0140097	catalytic activity, acting on DNA	IEP	HCCA
BP	GO:0140527	reciprocal homologous recombination	IEP	HCCA
BP	GO:1901361	organic cyclic compound catabolic process	IEP	HCCA
BP	GO:1902680	positive regulation of RNA biosynthetic process	IEP	HCCA
BP	GO:1903046	meiotic cell cycle process	IEP	HCCA
BP	GO:1903508	positive regulation of nucleic acid-templated transcription	IEP	HCCA
BP	GO:2000232	regulation of rRNA processing	IEP	HCCA
BP	GO:2000234	positive regulation of rRNA processing	IEP	HCCA

InterPro domains	Description	Start	Stop
IPR003347	JmjC_dom	66	182
IPR004198	Znf_C5HC2	276	328
IPR013637	Lys_sp_deMease-like_dom	545	636
IPR013637	Lys_sp_deMease-like_dom	647	834

External Links

No external refs found!

AT1G63490

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation