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GO:1904091: non-ribosomal peptide synthetase activity (Molecular function)

"Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization." [PMID:10631508, PMID:17502372]


There are 834 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_95 Angiopteris evecta 0.69 % 0.008693 0.023404
Cluster_134 Alsophila spinulosa 1.03 % 2.2e-05 0.001777
Cluster_92 Amborella trichopoda 1.57 % 2.1e-05 0.000328
Cluster_13 Cyanophora paradoxa 0.69 % 0.017387 0.048942
Cluster_182 Dicranopteris curranii 2.33 % 0.000828 0.016198
Cluster_175 Lindsaea ensifolia 2.38 % 0.0007 0.009526
Cluster_181 Nephrolepis biserrata 1.54 % 0.001439 0.0439
Cluster_199 Pleocnemia irregularis 1.28 % 0.002335 0.028841
Cluster_108 Psilotum nudum 1.56 % 0.001876 0.012124
Cluster_32 Tectaria incisa 0.7 % 0.003071 0.030814
Cluster_115 Arabidopsis thaliana 1.27 % 0.002857 0.011924
Sequences (834) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms