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GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity (Molecular function)

"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH." [PMID:29224355, RHEA:15989]


There are 2524 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_99 Abrodictyum obscurum 1.25 % 0.005525 0.036837
Cluster_87 Actinostachys digitata 1.05 % 0.000251 0.003523
Cluster_69 Azolla filiculoides 1.0 % 0.014707 0.041401
Cluster_127 Amblovenatum opulentum 4.51 % 0.0 0.0
Cluster_111 Alsophila spinulosa 1.13 % 0.000169 0.014424
Cluster_96 Amborella trichopoda 0.95 % 0.003844 0.014212
Cluster_14 Cibotium barometz 1.96 % 0.00322 0.046863
Cluster_209 Dicranopteris curranii 2.27 % 0.003383 0.035242
Cluster_126 Ginkgo biloba 4.26 % 0.000192 0.014946
Cluster_76 Ginkgo biloba 2.54 % 1.8e-05 0.003252
Cluster_55 Ginkgo biloba 1.09 % 0.002881 0.022469
Cluster_370 Picea abies 50.0 % 0.00054 0.019988
Cluster_104 Picea abies 5.36 % 0.0 5.9e-05
Cluster_233 Pyrrosia piloselloides 0.58 % 0.010691 0.038415
Cluster_294 Pyrrosia piloselloides 2.33 % 0.002665 0.046312
Cluster_208 Stenochlaena palustris 4.88 % 5e-06 0.000387
Cluster_120 Tectaria incisa 2.08 % 0.005144 0.028464
Cluster_435 Zea mays 50.0 % 0.000144 0.005339
Sequences (2524) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms