Pir_g18492 (MLH1, ATMLH1)

Aliases : MLH1, ATMLH1

Description : component *(MLH1) of MLH1-PMS1 heterodimer & original description: none

Gene families : OG0003563 (OrthoFinder output from all 47 species) Phylogenetic Tree(s): OG0003563_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: Pir_g18492

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	Interproscan
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004842	ubiquitin-protein transferase activity	IEP	HCCA
MF	GO:0004857	enzyme inhibitor activity	IEP	HCCA
MF	GO:0004864	protein phosphatase inhibitor activity	IEP	HCCA
MF	GO:0004865	protein serine/threonine phosphatase inhibitor activity	IEP	HCCA
BP	GO:0009892	negative regulation of metabolic process	IEP	HCCA
BP	GO:0010563	negative regulation of phosphorus metabolic process	IEP	HCCA
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	HCCA
BP	GO:0010921	regulation of phosphatase activity	IEP	HCCA
BP	GO:0010923	negative regulation of phosphatase activity	IEP	HCCA
MF	GO:0019208	phosphatase regulator activity	IEP	HCCA
MF	GO:0019212	phosphatase inhibitor activity	IEP	HCCA
BP	GO:0019220	regulation of phosphate metabolic process	IEP	HCCA
MF	GO:0019787	ubiquitin-like protein transferase activity	IEP	HCCA
MF	GO:0019888	protein phosphatase regulator activity	IEP	HCCA
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	HCCA
BP	GO:0031399	regulation of protein modification process	IEP	HCCA
BP	GO:0031400	negative regulation of protein modification process	IEP	HCCA
BP	GO:0032515	negative regulation of phosphoprotein phosphatase activity	IEP	HCCA
BP	GO:0035303	regulation of dephosphorylation	IEP	HCCA
BP	GO:0035304	regulation of protein dephosphorylation	IEP	HCCA
BP	GO:0035305	negative regulation of dephosphorylation	IEP	HCCA
BP	GO:0035308	negative regulation of protein dephosphorylation	IEP	HCCA
BP	GO:0043086	negative regulation of catalytic activity	IEP	HCCA
BP	GO:0043666	regulation of phosphoprotein phosphatase activity	IEP	HCCA
BP	GO:0044092	negative regulation of molecular function	IEP	HCCA
BP	GO:0045936	negative regulation of phosphate metabolic process	IEP	HCCA
BP	GO:0048519	negative regulation of biological process	IEP	HCCA
BP	GO:0048523	negative regulation of cellular process	IEP	HCCA
MF	GO:0050660	flavin adenine dinucleotide binding	IEP	HCCA
BP	GO:0050790	regulation of catalytic activity	IEP	HCCA
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	HCCA
BP	GO:0051174	regulation of phosphorus metabolic process	IEP	HCCA
BP	GO:0051246	regulation of protein metabolic process	IEP	HCCA
BP	GO:0051248	negative regulation of protein metabolic process	IEP	HCCA
BP	GO:0051336	regulation of hydrolase activity	IEP	HCCA
BP	GO:0051346	negative regulation of hydrolase activity	IEP	HCCA
MF	GO:0061630	ubiquitin protein ligase activity	IEP	HCCA
MF	GO:0061659	ubiquitin-like protein ligase activity	IEP	HCCA
BP	GO:0065009	regulation of molecular function	IEP	HCCA
MF	GO:0140678	molecular function inhibitor activity	IEP	HCCA

InterPro domains	Description	Start	Stop
IPR032189	Mlh1_C	437	715
IPR013507	DNA_mismatch_S5_2-like	221	342

External Links

No external refs found!

Pir_g18492 (MLH1, ATMLH1)

Expression Profile

Co-expression Networks

Functional Annotation