Description : 17.2.2 hormone metabolism.auxin.signal transduction Encodes an auxin efflux carrier that is similar to bacterial membrane transporters. Root-specific role in the transport of auxin. Acts downstream of CTR1 and ethylene biosynthesis, in the same pathway as EIN2 and AUX1, and independent from EIN3 and EIN5/AIN1 pathway. In the root, the protein localizes apically in epidermal and lateral root cap cells and predominantly basally in cortical cells. Functions may be regulated by phosphorylation status. EIR1 expression is induced by brassinolide treatment in the brassinosteroid-insensitive br1 mutant. Gravistimulation resulted in asymmetric PIN2 distribution, with more protein degraded at the upper side of the gravistimulated root. Protein turnover is affected by the proteasome and by endosomal cycling. Plasma membrane-localized PIN proteins mediate a saturable efflux of auxin. PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. The action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. Membrane sterol composition is essential for the acquisition of PIN2 polarity. ETHYLENE INSENSITIVE ROOT 1 (EIR1)

Gene families : OG_01_0001724 (Gene family) Phylogenetic Tree(s): OG0001724_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR network (cutoff 100): GSVIVT01029266001
Cluster HCCA cluster: Cluster_160

Target Alias Description ECC score Gene Family Method Actions
GSVIVT01019125001 No alias 17.2.2 hormone metabolism.auxin.signal transduction... 0.02 Gene family
Zm00001d044083 GRMZM2G126260 17.2.2 hormone metabolism.auxin.signal transduction... 0.02 Gene family

Type GO Term Name Evidence Source
CC GO:0016021 integral component of membrane IEA InterProScan
BP GO:0055085 transmembrane transport IEA InterProScan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR004776 Mem_trans 213 432
IPR004776 Mem_trans 10 70
No external refs found!