Description : 30.8 signalling.misc Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation. KU80

Gene families : OG_01_0002608 (Gene family) Phylogenetic Tree(s): OG0002608_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR network (cutoff 100): GSVIVT01027610001
Cluster HCCA cluster: Cluster_128

Type GO Term Name Evidence Source
MF GO:0003677 DNA binding IEA InterProScan
BP GO:0006303 double-strand break repair via nonhomologous end joining IEA InterProScan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR005160 Ku_C 436 507
IPR014893 Ku_PK_bind 550 665
IPR006164 Ku70/Ku80_beta-barrel_dom 209 414
IPR005161 Ku_N 11 137
No external refs found!