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GO:0140358: P-type transmembrane transporter activity (Molecular function)

"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]


There are 496 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_190 Azolla filiculoides 1.31 % 0.001537 0.029197
Cluster_239 Arabidopsis thaliana 50.0 % 0.002963 0.032593
Cluster_135 Arabidopsis thaliana 4.17 % 0.002317 0.011081
Cluster_69 Arabidopsis thaliana 3.33 % 0.003595 0.041698
Cluster_138 Arabidopsis thaliana 4.88 % 0.001695 0.049585
Sequences (496) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms