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GO:0140223: general transcription initiation factor activity (Molecular function)

"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]


There are 621 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_187 Abrodictyum obscurum 0.59 % 0.003921 0.043295
Cluster_122 Actinostachys digitata 0.58 % 0.00524 0.022709
Cluster_104 Angiopteris evecta 0.69 % 0.002886 0.014053
Cluster_120 Adiantum latifolium 1.23 % 0.002045 0.00814
Cluster_102 Alsophila latebrosa 1.06 % 0.002924 0.023891
Cluster_53 Amblovenatum opulentum 0.63 % 0.004416 0.047335
Sequences (621) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms