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GO:0140223: general transcription initiation factor activity (Molecular function)

"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]


There are 621 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_187 Abrodictyum obscurum 0.57 % 0.004036 0.042785
Cluster_120 Adiantum latifolium 1.15 % 0.002196 0.007828
Cluster_102 Alsophila latebrosa 1.04 % 0.002986 0.027712
Cluster_471 Amblovenatum opulentum 1.79 % 0.001566 0.026624
Cluster_53 Amblovenatum opulentum 0.53 % 0.005225 0.040463
Cluster_104 Angiopteris evecta 0.62 % 0.003207 0.015615
Cluster_523 Davallia denticulata 1.41 % 0.00135 0.02924
Cluster_565 Lindsaea ensifolia 0.88 % 0.001882 0.048471
Cluster_9 Microlepia speluncae 0.4 % 0.005168 0.029976
Cluster_567 Pleocnemia irregularis 0.79 % 0.003771 0.033563
Cluster_475 Pleocnemia irregularis 1.85 % 0.001617 0.040426
Cluster_431 Salvinia molesta 1.82 % 0.001034 0.015603
Cluster_367 Tectaria incisa 1.1 % 0.001954 0.010073
Cluster_447 Diplazium proliferum (Lam.) Kaulf. 1.59 % 0.001355 0.015417
Cluster_589 Pyrrosia piloselloides 1.72 % 0.0009 0.013945
Cluster_427 Ophioglossum reticulatum 1.72 % 0.001271 0.01377
Cluster_466 Stenochlaena palustris 0.79 % 0.002193 0.047147
Cluster_459 Dicranopteris curranii 0.94 % 0.00204 0.027396
Cluster_425 Alsophila spinulosa 2.33 % 0.001203 0.021133
Sequences (621) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms