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GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


There are 5877 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_59 Abrodictyum obscurum 1.28 % 0.012526 0.033106
Cluster_86 Actinostachys digitata 1.63 % 7e-06 0.000179
Cluster_29 Azolla filiculoides 2.24 % 4e-05 0.001477
Cluster_66 Azolla filiculoides 1.08 % 0.003839 0.039926
Cluster_120 Adiantum latifolium 2.47 % 0.000269 0.001669
Cluster_166 Adiantum latifolium 25.0 % 0.001211 0.046023
Cluster_227 Alsophila latebrosa 2.38 % 0.009113 0.03987
Cluster_22 Amblovenatum opulentum 3.23 % 0.000112 0.004826
Cluster_188 Cibotium barometz 1.82 % 0.01038 0.04053
Cluster_129 Lindsaea ensifolia 1.63 % 0.00032 0.001157
Cluster_125 Microlepia speluncae 1.09 % 0.000905 0.019526
Cluster_16 Microlepia speluncae 1.92 % 0.012674 0.04617
Cluster_9 Nephrolepis biserrata 1.1 % 0.001027 0.003585
Cluster_39 Nephrolepis biserrata 1.03 % 0.025476 0.048768
Cluster_134 Pleocnemia irregularis 1.43 % 0.001073 0.016186
Cluster_168 Stenochlaena palustris 3.23 % 0.000215 0.014616
Cluster_130 Arabidopsis thaliana 7.41 % 0.0 1e-06
Sequences (5877) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !