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GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


There are 5877 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_130 Arabidopsis thaliana 5.71 % 0.0 2e-06
Cluster_376 Abrodictyum obscurum 1.89 % 0.008526 0.04076
Cluster_296 Abrodictyum obscurum 1.47 % 0.000203 0.00502
Cluster_120 Adiantum latifolium 2.3 % 0.00031 0.001904
Cluster_446 Adiantum latifolium 25.0 % 0.001211 0.046023
Cluster_480 Alsophila latebrosa 2.38 % 0.000152 0.029204
Cluster_422 Alsophila latebrosa 2.25 % 0.000171 0.002561
Cluster_22 Amblovenatum opulentum 2.6 % 0.000173 0.00823
Cluster_527 Angiopteris evecta 1.85 % 0.0054 0.01482
Cluster_372 Angiopteris evecta 1.79 % 0.005599 0.024044
Cluster_526 Davallia denticulata 1.59 % 0.014277 0.047971
Cluster_103 Equisetum hyemale 3.51 % 0.000273 0.002429
Cluster_129 Lindsaea ensifolia 1.47 % 0.000391 0.001476
Cluster_16 Microlepia speluncae 1.43 % 0.017027 0.049265
Cluster_125 Microlepia speluncae 0.81 % 0.001606 0.03768
Cluster_9 Nephrolepis biserrata 0.87 % 0.001634 0.00675
Cluster_134 Pleocnemia irregularis 1.3 % 0.001296 0.017444
Cluster_370 Pleocnemia irregularis 1.15 % 0.001648 0.032049
Cluster_522 Pyrrosia piloselloides 1.16 % 0.022441 0.04369
Cluster_420 Pyrrosia piloselloides 2.38 % 0.000225 0.006984
Cluster_218 Ophioglossum reticulatum 1.3 % 0.016749 0.049761
Cluster_330 Ophioglossum reticulatum 0.91 % 0.001006 0.003836
Cluster_168 Stenochlaena palustris 2.5 % 0.000358 0.024333
Cluster_255 Dicranopteris curranii 0.8 % 0.021447 0.037642
Cluster_352 Dicranopteris curranii 1.16 % 0.0148 0.03616
Cluster_353 Dicranopteris curranii 1.52 % 0.011376 0.031432
Cluster_369 Lygodium flexuosum 1.79 % 0.012138 0.028944
Cluster_206 Lygodium flexuosum 1.64 % 0.013215 0.034212
Cluster_367 Lygodium flexuosum 1.47 % 0.014722 0.043725
Sequences (5877) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !