GO:0004662: CAAX-protein geranylgeranyltransferase activity (Molecular function)

"Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]


There are 1 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Sequences (1) (download table)

InterPro Domains

GO Terms

Family Terms