GO:0086095: positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (Biological process)

"A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]

There are 0 sequences with this label.

Enriched clusters

Name	Species	% in cluster	p-value	corrected p-value	action
No clusters are enriched for this term

Sequences (0) (download table)

InterPro Domains

GO Terms

Family Terms

GO:0086095: positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (Biological process)

Associations