GO:0086094: positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction (Biological process)

"An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]

There are 0 sequences with this label.

Enriched clusters

Name	Species	% in cluster	p-value	corrected p-value	action
No clusters are enriched for this term

Sequences (0) (download table)

InterPro Domains

GO Terms

Family Terms

GO:0086094: positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction (Biological process)

Associations