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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


There are 309 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_107 Amborella trichopoda 1.94 % 0.001518 0.006866
Cluster_116 Arabidopsis thaliana 1.9 % 0.004711 0.012805
Cluster_175 Arabidopsis thaliana 2.05 % 0.000384 0.001664
Cluster_81 Arabidopsis thaliana 2.86 % 0.002128 0.007527
Cluster_139 Cyanophora paradoxa 1.94 % 0.003115 0.022625
Cluster_27 Gingko biloba 1.14 % 0.000595 0.012584
Cluster_271 Gingko biloba 3.77 % 0.000515 0.008299
Cluster_64 Gingko biloba 0.96 % 0.007644 0.036837
Cluster_171 Marchantia polymorpha 3.12 % 0.004098 0.048088
Cluster_101 Marchantia polymorpha 5.56 % 7.1e-05 0.011569
Cluster_53 Marchantia polymorpha 3.67 % 2e-05 0.000714
Cluster_263 Oryza sativa 2.94 % 0.000942 0.027153
Cluster_344 Oryza sativa 6.25 % 4e-06 0.000746
Cluster_656 Oryza sativa 50.0 % 0.001327 0.013933
Cluster_328 Picea abies 1.82 % 0.026889 0.043164
Cluster_86 Picea abies 2.06 % 0.001075 0.006302
Cluster_417 Picea abies 2.27 % 0.000887 0.007071
Cluster_176 Picea abies 2.33 % 0.000847 0.008752
Cluster_13 Solanum lycopersicum 1.46 % 0.001119 0.007057
Cluster_170 Solanum lycopersicum 2.42 % 0.000259 0.002091
Cluster_59 Zea mays 1.72 % 0.001879 0.005172
Cluster_295 Zea mays 1.12 % 0.004394 0.020146
Cluster_49 Zea mays 1.23 % 0.000324 0.009113
Cluster_273 Zea mays 2.79 % 0.0 5e-06
Sequences (309) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms