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GO:0004252: serine-type endopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


There are 21060 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_28 Amborella trichopoda 6.11 % 0.0 2e-06
Cluster_232 Amborella trichopoda 3.23 % 0.005286 0.031716
Cluster_61 Amborella trichopoda 4.92 % 0.001599 0.028587
Cluster_74 Amborella trichopoda 8.26 % 0.0 0.0
Cluster_203 Arabidopsis thaliana 3.39 % 0.009578 0.04423
Cluster_269 Arabidopsis thaliana 7.14 % 0.000159 0.004435
Cluster_140 Arabidopsis thaliana 3.33 % 0.009892 0.048247
Cluster_77 Chlamydomonas reinhardtii 3.39 % 0.011118 0.019406
Cluster_156 Cyanophora paradoxa 6.38 % 0.000444 0.048878
Cluster_21 Cyanophora paradoxa 2.76 % 0.00116 0.018669
Cluster_1 Cyanophora paradoxa 2.52 % 0.006378 0.034487
Cluster_100 Gingko biloba 5.41 % 9e-06 7.1e-05
Cluster_511 Gingko biloba 100.0 % 3e-06 5.4e-05
Cluster_126 Gingko biloba 4.08 % 0.003341 0.048448
Cluster_336 Gingko biloba 5.36 % 0.000132 0.004741
Cluster_26 Marchantia polymorpha 2.38 % 0.006957 0.023096
Cluster_106 Marchantia polymorpha 3.51 % 0.003266 0.033677
Cluster_360 Oryza sativa 2.82 % 0.008702 0.026107
Cluster_135 Oryza sativa 2.86 % 0.008468 0.032493
Cluster_68 Oryza sativa 4.84 % 0.000255 0.004979
Cluster_183 Oryza sativa 3.57 % 0.005497 0.019882
Cluster_48 Oryza sativa 2.13 % 0.002762 0.008211
Cluster_81 Oryza sativa 3.65 % 8e-06 0.001566
Cluster_199 Selaginella moellendorffii 3.77 % 0.001132 0.013133
Cluster_336 Selaginella moellendorffii 50.0 % 0.001884 0.005651
Cluster_225 Solanum lycopersicum 4.41 % 0.001483 0.012883
Cluster_113 Solanum lycopersicum 5.56 % 1.2e-05 0.001875
Cluster_247 Solanum lycopersicum 3.3 % 0.003404 0.049352
Cluster_216 Solanum lycopersicum 3.16 % 0.003841 0.017414
Cluster_115 Solanum lycopersicum 10.34 % 0.0 1e-06
Cluster_290 Solanum lycopersicum 5.36 % 0.000844 0.022226
Cluster_55 Solanum lycopersicum 1.58 % 0.024969 0.048038
Cluster_20 Vitis vinifera 3.74 % 7e-06 0.001578
Cluster_28 Vitis vinifera 2.41 % 0.003728 0.020064
Cluster_470 Vitis vinifera 50.0 % 0.007577 0.045462
Cluster_366 Vitis vinifera 25.0 % 0.015097 0.04618
Cluster_73 Vitis vinifera 3.6 % 0.000857 0.016721
Cluster_51 Zea mays 2.21 % 0.000367 0.003594
Cluster_71 Zea mays 1.55 % 0.024021 0.041106
Cluster_344 Zea mays 2.35 % 0.010944 0.039123
Cluster_202 Zea mays 2.9 % 0.00733 0.040314
Cluster_109 Zea mays 2.74 % 0.008172 0.044945
Cluster_292 Picea abies 2.44 % 0.008229 0.040734
Cluster_134 Picea abies 3.85 % 0.000304 0.002369
Cluster_711 Picea abies 14.29 % 0.011499 0.026065
Cluster_136 Picea abies 4.17 % 0.00024 0.00242
Cluster_266 Picea abies 1.71 % 0.003128 0.012771
Cluster_295 Picea abies 2.21 % 0.00153 0.016554
Cluster_169 Picea abies 1.72 % 0.015938 0.039488
Cluster_629 Picea abies 100.0 % 3e-06 4.9e-05
Cluster_253 Picea abies 7.94 % 0.0 8e-06
Cluster_216 Abrodictyum obscurum 1.04 % 0.005972 0.023181
Cluster_312 Adiantum latifolium 3.39 % 0.000923 0.04894
Cluster_9 Adiantum latifolium 1.1 % 0.008302 0.037033
Cluster_416 Adiantum latifolium 3.23 % 0.001019 0.037706
Cluster_577 Alsophila latebrosa 3.77 % 0.000646 0.019057
Cluster_489 Alsophila latebrosa 1.43 % 0.004388 0.035457
Cluster_148 Amblovenatum opulentum 2.94 % 9.6e-05 0.001103
Cluster_403 Amblovenatum opulentum 5.71 % 0.0 4.9e-05
Cluster_95 Angiopteris evecta 1.04 % 0.001928 0.011291
Cluster_174 Angiopteris evecta 1.52 % 0.022253 0.048268
Cluster_474 Lindsaea ensifolia 1.04 % 0.008136 0.034832
Cluster_109 Lindsaea ensifolia 1.97 % 0.00017 0.008156
Cluster_79 Microlepia speluncae 0.85 % 0.008484 0.037074
Cluster_221 Microlepia speluncae 4.69 % 8e-06 0.001155
Cluster_17 Microlepia speluncae 0.84 % 0.008765 0.038008
Cluster_154 Nephrolepis biserrata 1.85 % 0.000228 0.01401
Cluster_693 Pleocnemia irregularis 50.0 % 0.001557 0.018686
Cluster_350 Psilotum nudum 3.57 % 0.000398 0.042618
Cluster_6 Psilotum nudum 1.47 % 0.002316 0.021536
Cluster_93 Salvinia molesta 5.0 % 0.0 0.0
Cluster_628 Salvinia molesta 25.0 % 0.009521 0.013647
Cluster_517 Salvinia molesta 4.35 % 0.00547 0.049913
Cluster_221 Salvinia molesta 5.88 % 0.000255 0.000772
Cluster_46 Salvinia molesta 10.47 % 0.0 0.0
Cluster_60 Salvinia molesta 9.59 % 0.0 0.0
Cluster_51 Salvinia molesta 2.63 % 0.014377 0.043383
Cluster_193 Salvinia molesta 7.78 % 0.0 0.0
Cluster_81 Salvinia molesta 2.25 % 0.000204 0.004547
Cluster_50 Salvinia molesta 4.95 % 5e-06 0.00036
Cluster_28 Salvinia molesta 3.45 % 0.000181 0.001371
Cluster_325 Salvinia molesta 5.88 % 0.000255 0.000382
Cluster_523 Diplazium proliferum (Lam.) Kaulf. 2.4 % 0.000107 0.0101
Cluster_197 Pyrrosia piloselloides 2.27 % 0.001913 0.024556
Cluster_236 Pyrrosia piloselloides 1.9 % 0.002708 0.028026
Cluster_365 Pyrrosia piloselloides 2.56 % 0.001508 0.014327
Cluster_740 Pyrrosia piloselloides 50.0 % 0.001458 0.026237
Cluster_160 Pyrrosia piloselloides 1.02 % 0.009087 0.048286
Cluster_513 Ophioglossum reticulatum 4.17 % 0.000225 0.003976
Cluster_333 Ophioglossum reticulatum 1.07 % 0.003333 0.028805
Cluster_347 Stenochlaena palustris 2.99 % 0.002195 0.032493
Cluster_126 Stenochlaena palustris 1.48 % 0.008589 0.038855
Cluster_95 Stenochlaena palustris 1.75 % 1.2e-05 0.000131
Cluster_366 Dicranopteris curranii 1.85 % 0.004354 0.022691
Cluster_803 Dicranopteris curranii 2.4 % 0.000204 0.007905
Cluster_808 Dicranopteris curranii 50.0 % 0.001808 0.032551
Cluster_706 Dicranopteris curranii 50.0 % 0.001808 0.041593
Cluster_372 Alsophila spinulosa 3.33 % 0.000762 0.00758
Cluster_58 Alsophila spinulosa 1.18 % 0.005835 0.024279
Cluster_30 Lygodium flexuosum 2.82 % 0.001228 0.045863
Sequences (21060) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !