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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


There are 19902 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_179 Abrodictyum obscurum 4.76 % 0.000534 0.020831
Cluster_162 Actinostachys digitata 2.58 % 3e-06 0.000286
Cluster_26 Actinostachys digitata 4.35 % 0.00036 0.036011
Cluster_68 Angiopteris evecta 1.11 % 0.004281 0.017607
Cluster_119 Azolla filiculoides 3.81 % 0.000244 0.004691
Cluster_89 Adiantum latifolium 2.29 % 1.2e-05 0.000629
Cluster_213 Alsophila latebrosa 2.0 % 0.000134 0.000895
Cluster_210 Alsophila latebrosa 1.65 % 0.000237 0.009529
Cluster_584 Amblovenatum opulentum 33.33 % 0.002223 0.017781
Cluster_48 Amblovenatum opulentum 1.59 % 0.000387 0.004804
Cluster_36 Amblovenatum opulentum 1.29 % 0.005986 0.021731
Cluster_288 Cibotium barometz 1.54 % 0.001453 0.013028
Cluster_149 Ceratopteris richardii 3.23 % 0.002747 0.012405
Cluster_60 Ceratopteris richardii 4.26 % 6e-06 0.001115
Cluster_116 Ceratopteris richardii 2.91 % 0.000295 0.010577
Cluster_198 Diplazium proliferum (Lam.) Kaulf. 50.0 % 0.001634 0.015254
Cluster_333 Dicranopteris curranii 33.33 % 0.00202 0.022215
Cluster_119 Davallia denticulata 1.96 % 0.000453 0.00408
Cluster_6 Davallia denticulata 2.38 % 0.000257 0.006677
Cluster_99 Davallia denticulata 1.05 % 0.014729 0.048001
Cluster_135 Ginkgo biloba 1.82 % 0.00219 0.010391
Cluster_177 Ginkgo biloba 4.88 % 0.000308 0.020922
Cluster_39 Ginkgo biloba 1.14 % 0.005485 0.047012
Cluster_48 Lindsaea ensifolia 1.36 % 0.002815 0.01445
Cluster_3 Marchantia polymorpha 1.55 % 0.002919 0.011203
Cluster_89 Nephrolepis biserrata 1.61 % 0.006274 0.04784
Cluster_27 Nephrolepis biserrata 4.17 % 0.000972 0.034489
Cluster_165 Nephrolepis biserrata 1.65 % 0.005984 0.02081
Cluster_152 Ophioglossum reticulatum 5.26 % 7e-06 7.6e-05
Cluster_158 Ophioglossum reticulatum 1.13 % 0.00606 0.030016
Cluster_460 Oryza sativa 50.0 % 0.001327 0.013933
Cluster_100 Picea abies 1.89 % 6.9e-05 0.000341
Cluster_226 Pleocnemia irregularis 1.78 % 0.00077 0.017593
Cluster_4 Psilotum nudum 1.09 % 0.01202 0.047319
Cluster_208 Salvinia molesta 50.0 % 0.001842 0.016582
Cluster_46 Salvinia molesta 1.24 % 0.009763 0.014023
Cluster_133 Solanum lycopersicum 1.1 % 0.01408 0.038937
Cluster_38 Solanum lycopersicum 1.33 % 0.009847 0.031676
Cluster_26 Solanum lycopersicum 2.25 % 0.003584 0.049755
Cluster_42 Selaginella moellendorffii 1.52 % 0.002962 0.021254
Cluster_127 Stenochlaena palustris 4.44 % 0.000964 0.022013
Cluster_63 Stenochlaena palustris 1.38 % 0.009531 0.036067
Cluster_582 Stenochlaena palustris 50.0 % 0.002018 0.01816
Cluster_2 Tectaria incisa 1.02 % 0.010208 0.025229
Cluster_190 Tectaria incisa 33.33 % 0.002318 0.039402
Cluster_28 Zea mays 3.65 % 0.0 3e-06
Cluster_120 Zea mays 2.27 % 0.001089 0.010731
Cluster_117 Arabidopsis thaliana 2.17 % 0.00364 0.012559
Cluster_5 Arabidopsis thaliana 1.77 % 0.005434 0.015605
Sequences (19902) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !