"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
There are 132 sequences with this label.
Name | Species | % in cluster | p-value | corrected p-value | action |
---|---|---|---|---|---|
Cluster_93 | Arabidopsis thaliana | 2.9 % | 0.002601 | 0.019056 | |
Cluster_376 | Oryza sativa | 50.0 % | 0.000901 | 0.014413 | |
Cluster_148 | Oryza sativa | 1.83 % | 5.3e-05 | 0.000449 | |
Cluster_76 | Picea abies | 2.08 % | 0.009403 | 0.018807 | |
Cluster_309 | Solanum lycopersicum | 3.39 % | 0.000636 | 0.013841 | |
Cluster_37 | Solanum lycopersicum | 1.52 % | 0.000252 | 0.004326 | |
Cluster_208 | Zea mays | 4.0 % | 0.000302 | 0.022919 | |
Cluster_86 | Zea mays | 0.87 % | 0.006186 | 0.04136 | |
Cluster_271 | Zea mays | 2.41 % | 0.000829 | 0.038148 | |
Cluster_507 | Zea mays | 50.0 % | 0.001025 | 0.012646 | |
Cluster_555 | Zea mays | 50.0 % | 0.001025 | 0.016406 | |
Cluster_344 | Zea mays | 6.0 % | 2e-06 | 0.00016 |