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GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 132 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_93 Arabidopsis thaliana 2.9 % 0.002601 0.019056
Cluster_376 Oryza sativa 50.0 % 0.000901 0.014413
Cluster_148 Oryza sativa 1.83 % 5.3e-05 0.000449
Cluster_76 Picea abies 2.08 % 0.009403 0.018807
Cluster_309 Solanum lycopersicum 3.39 % 0.000636 0.013841
Cluster_37 Solanum lycopersicum 1.52 % 0.000252 0.004326
Cluster_208 Zea mays 4.0 % 0.000302 0.022919
Cluster_86 Zea mays 0.87 % 0.006186 0.04136
Cluster_271 Zea mays 2.41 % 0.000829 0.038148
Cluster_507 Zea mays 50.0 % 0.001025 0.012646
Cluster_555 Zea mays 50.0 % 0.001025 0.016406
Cluster_344 Zea mays 6.0 % 2e-06 0.00016
Sequences (132) (download table)

InterPro Domains

GO Terms

Family Terms