1. Home
  2. GO
  3. GO:0016592

GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 7823 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_25 Azolla filiculoides 4.88 % 0.000269 0.008519
Cluster_92 Adiantum latifolium 1.05 % 0.001724 0.011396
Cluster_443 Amblovenatum opulentum 50.0 % 0.000531 0.006909
Cluster_84 Alsophila spinulosa 1.02 % 0.000775 0.006166
Cluster_109 Amborella trichopoda 1.14 % 0.004617 0.038068
Cluster_56 Cyanophora paradoxa 2.04 % 0.021609 0.047188
Cluster_164 Dicranopteris curranii 2.0 % 0.01244 0.048324
Cluster_10 Equisetum hyemale 1.06 % 0.002127 0.028582
Cluster_164 Microlepia speluncae 5.56 % 0.0 2.3e-05
Cluster_150 Microlepia speluncae 2.27 % 0.010734 0.040008
Cluster_10 Marchantia polymorpha 1.14 % 0.005965 0.034578
Cluster_150 Oryza sativa 2.63 % 0.000481 0.017024
Cluster_61 Salvinia cucullata 1.45 % 0.003007 0.043675
Cluster_303 Stenochlaena palustris 50.0 % 0.000522 0.013573
Cluster_84 Stenochlaena palustris 1.33 % 0.000695 0.007072
Sequences (7823) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !